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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313525
Species: Homo sapiens
RGD Object: Gene
Symbol: MKI67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MKI67affects phosphorylationEXP 6480464CTDQuercetin affects the phosphorylation of MKI67 proteinPMID:35688186
MKI67multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Quercetin] results in decreased expression of MKI67 protein; [Quercetin co-treated with Ascorbic Acid] results in increased expression of MKI67 mRNAPMID:16082193 PMID:17639512
MKI67decreases expressionISOMki67 (Mus musculus)6480464CTDQuercetin results in decreased expression of MKI67 proteinPMID:15067354
MKI67multiple interactionsISOMki67 (Mus musculus)6480464CTDQuercetin promotes the reaction [Tamoxifen results in decreased expression of MKI67 protein]PMID:15067354
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