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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10708
Species: Mus musculus
RGD Object: Gene
Symbol: Hgf
Name: hepatocyte growth factor
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hgfmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Methylnitrosourea results in decreased expression of HGF mRNA]PMID:18675455
Hgfdecreases expressionISOHGF (Homo sapiens)6480464CTDQuercetin results in decreased expression of HGF mRNAPMID:25971889
Hgfmultiple interactionsISOHGF (Homo sapiens)6480464CTDQuercetin inhibits the reaction [HGF protein promotes the reaction [bis(sulfosuccinimidyl)suberate promotes the reaction [MET protein binds to MET protein]]]; Quercetin inhibits the reaction [HGF protein results in increased expression of and results in increased phosphorylation of MET protein]; Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of GAB1 protein]; Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]; Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of PTK2 protein]PMID:19244381 PMID:25971889
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