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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736832
Species: Homo sapiens
RGD Object: Gene
Symbol: EGF
Name: epidermal growth factor
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of EGFPMID:30265530
EGFmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]PMID:30265530
EGFdecreases expressionISOEgf (Mus musculus)6480464CTDHydrogen Peroxide results in decreased expression of EGF mRNAPMID:17997286
EGFmultiple interactionsISOEgf (Mus musculus)6480464CTDSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGF mRNA]PMID:17997286
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