Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceEXP 6480464CTDGPX4 protein results in decreased susceptibility to Hydrogen Peroxide, GPX4 results in decreased susceptibility to Hydrogen Peroxide

PMID:12566075, PMID:18206984
increases response to substanceEXP 6480464CTDGPX4 gene mutant form results in increased susceptibility to Hydrogen Peroxide

PMID:12566075
decreases response to substanceISORGD:7360496480464CTDGPX4 protein results in decreased susceptibility to Hydrogen Peroxide

PMID:14660625
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.