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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735698
Species: Homo sapiens
RGD Object: Gene
Symbol: FGF1
Name: fibroblast growth factor 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FGF1decreases expressionISOFgf1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in decreased expression of FGF1 mRNAPMID:31332898
FGF1decreases response to substanceISOFgf1 (Mus musculus)6480464CTDFGF1 protein results in decreased susceptibility to Hydrogen PeroxidePMID:16222742
FGF1multiple interactionsISOFgf1 (Rattus norvegicus)6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]; [3,4-dihydroxyphenylethanol co-treated with Hydrogen Peroxide] results in increased expression of FGF1 mRNA; [Sirolimus co-treated with Hydrogen Peroxide] results in increased expression of FGF1 mRNA; Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]]PMID:31332898
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