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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735440
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKBIA
Name: NFKB inhibitor alpha
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKBIAaffects expressionEXP 6480464CTDHydrogen Peroxide affects the expression of NFKBIA mRNAPMID:23410634
NFKBIAdecreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of NFKBIA mRNA; Hydrogen Peroxide results in decreased expression of NFKBIA proteinPMID:15081873 PMID:31521693
NFKBIAdecreases response to substanceEXP 6480464CTDNFKBIA protein results in decreased susceptibility to Hydrogen PeroxidePMID:9989825
NFKBIAincreases cleavageEXP 6480464CTDHydrogen Peroxide results in increased cleavage of NFKBIA proteinPMID:21347231
NFKBIAincreases degradationEXP 6480464CTDHydrogen Peroxide results in increased degradation of NFKBIA proteinPMID:15081873 PMID:25305479 PMID:25321315
NFKBIAincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of NFKBIA mRNAPMID:9434740
NFKBIAincreases phosphorylationEXP 6480464CTDHydrogen Peroxide results in increased phosphorylation of NFKBIA proteinPMID:15142122 PMID:34499403
NFKBIAmultiple interactionsEXP 6480464CTD4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; [Hydrogen Peroxide results in increased cleavage of NFKBIA protein] which results in increased activity of RELA protein; Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein; Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased degradation of NFKBIA protein]; Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA protein]; Vitamin E inhibits the reaction [Hydrogen Peroxide results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]PMID:14753751 PMID:15081873 PMID:15142122 PMID:21347231 PMID:25305479 PMID:31521693 PMID:34499403
NFKBIAaffects degradationISONfkbia (Rattus norvegicus)6480464CTDHydrogen Peroxide affects the degradation of NFKBIA proteinPMID:10712386
NFKBIAaffects expressionISONfkbia (Mus musculus)6480464CTDHydrogen Peroxide affects the expression of NFKBIA proteinPMID:21599461
NFKBIAaffects response to substanceISONfkbia (Mus musculus)6480464CTDNFKBIA protein affects the susceptibility to Hydrogen PeroxidePMID:15746559
NFKBIAdecreases expressionISONfkbia (Mus musculus)6480464CTDHydrogen Peroxide results in decreased expression of NFKBIA proteinPMID:24558376
NFKBIAdecreases phosphorylationISONfkbia (Mus musculus)6480464CTDHydrogen Peroxide results in decreased phosphorylation of NFKBIA proteinPMID:18441283
NFKBIAincreases degradationISONfkbia (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased degradation of NFKBIA proteinPMID:16284289
NFKBIAincreases phosphorylationISONfkbia (Mus musculus)6480464CTDHydrogen Peroxide results in increased phosphorylation of NFKBIA proteinPMID:19010997 PMID:26447207
NFKBIAincreases phosphorylationISONfkbia (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased phosphorylation of NFKBIA proteinPMID:25451577
NFKBIAmultiple interactionsISONfkbia (Mus musculus)6480464CTDHydrogen Peroxide affects the localization of and results in increased activity of NFKBIA protein; NFKBIA gene mutant form inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTCF mRNA]; NFKBIA gene mutant form inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTCF protein]; NFKBIA protein mutant form inhibits the reaction [Hydrogen Peroxide results in increased expression of CAT mRNA]; PTPN6 protein inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of NFKBIA protein]; SN50 peptide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]PMID:11728812 PMID:18441283 PMID:24558376 PMID:26447207
NFKBIAmultiple interactionsISONfkbia (Rattus norvegicus)6480464CTD3,5-dicaffeoylquinic acid methyl ester inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]; Progesterone promotes the reaction [Hydrogen Peroxide results in increased degradation of NFKBIA protein]PMID:16284289 PMID:25451577
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