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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732766
Species: Mus musculus
RGD Object: Gene
Symbol: Ogg1
Name: 8-oxoguanine DNA-glycosylase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ogg1increases expressionISOOGG1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of OGG1 mRNAPMID:19651184
Ogg1increases response to substanceISOOGG1 (Homo sapiens)6480464CTDOGG1 mutant form results in increased susceptibility to Hydrogen Peroxide; OGG1 protein results in increased susceptibility to Hydrogen PeroxidePMID:25127756 PMID:34196753
Ogg1multiple interactionsISOOGG1 (Homo sapiens)6480464CTD[NUDT1 mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased expression of OGG1 mRNA; [OGG1 mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased expression of NUDT1 mRNA; Quercetin promotes the reaction [Hydrogen Peroxide results in increased expression of OGG1 mRNA]PMID:19651184 PMID:25127756
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