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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731644
Species: Homo sapiens
RGD Object: Gene
Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RPS6KB1decreases phosphorylationEXP 6480464CTDHydrogen Peroxide results in decreased phosphorylation of RPS6KB1 proteinPMID:19451193
RPS6KB1increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of RPS6KB1 proteinPMID:18603805
RPS6KB1increases phosphorylationEXP 6480464CTDHydrogen Peroxide results in increased phosphorylation of RPS6KB1 proteinPMID:36162953
RPS6KB1multiple interactionsEXP 6480464CTDepigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]PMID:36162953
RPS6KB1multiple interactionsISORps6kb1 (Rattus norvegicus)6480464CTD1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; [Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]; CAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]]; Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [Rotenone results in increased abundance of Hydrogen Peroxide]PMID:15705590 PMID:25304210
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