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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionISOTimp1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased expression of TIMP1 proteinPMID:20881940 PMID:23022513
Timp1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTDAscorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of TIMP1 protein]; tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of TIMP1 protein]PMID:20881940 PMID:23022513
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