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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69226
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases response to substanceISOGPX4 (Homo sapiens)6480464CTDGPX4 protein results in decreased susceptibility to Hydrogen PeroxidePMID:14660625
Gpx4decreases response to substanceISOGpx4 (Mus musculus)6480464CTDGPX4 protein results in decreased susceptibility to Hydrogen Peroxide; GPX4 results in decreased susceptibility to Hydrogen PeroxidePMID:12566075 PMID:18206984
Gpx4increases response to substanceISOGpx4 (Mus musculus)6480464CTDGPX4 gene mutant form results in increased susceptibility to Hydrogen PeroxidePMID:12566075
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