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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGaffects expressionEXP 6480464CTDHydrogen Peroxide affects the expression of PPARG mRNAPMID:20044591
PPARGdecreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of PPARG proteinPMID:27417252 PMID:34499403
PPARGincreases degradationEXP 6480464CTDHydrogen Peroxide results in increased degradation of PPARG proteinPMID:25305479
PPARGincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of PPARG mRNAPMID:25130202
PPARGmultiple interactionsEXP 6480464CTDbergenin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARG protein]; Hydrogen Peroxide results in increased phosphorylation of and results in decreased activity of PPARG protein; myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of PPARG mRNA]; Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased degradation of PPARG protein]; Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased degradation of PPARG protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]PMID:17030193 PMID:25130202 PMID:25305479 PMID:34499403
PPARGaffects abundanceISOPparg (Mus musculus)6480464CTDPPARG protein affects the abundance of Hydrogen PeroxidePMID:18083318
PPARGdecreases abundanceISOPparg (Mus musculus)6480464CTDPPARG gene polymorphism results in decreased abundance of Hydrogen PeroxidePMID:18083318
PPARGdecreases expressionISOPparg (Rattus norvegicus)6480464CTDHydrogen Peroxide results in decreased expression of PPARG proteinPMID:17302992
PPARGmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDstearic acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARG protein]PMID:17302992
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