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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDHydrogen Peroxide results in increased activity of CASP12 protein

PMID:25065601
increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of CASP12 protein modified form

PMID:22081883
multiple interactionsEXP 6480464CTDcalycopterin results in decreased susceptibility to [Hydrogen Peroxide results in increased expression of CASP12 protein modified form], PBK protein inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP12 protein]

PMID:22081883, PMID:25065601
increases cleavageISORGD:7314426480464CTDHydrogen Peroxide results in increased cleavage of CASP12 protein

PMID:20878536
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.