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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3838
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdx2
Name: peroxiredoxin 2
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of PRDX2 protein

PMID:23178681
increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of PRDX2 protein modified form

PMID:16178011
decreases expressionISORGD:7354776480464CTDHydrogen Peroxide results in decreased expression of PRDX2 mRNA

PMID:14729362
decreases response to substanceISORGD:7330196480464CTDPRDX2 protein results in decreased susceptibility to Hydrogen Peroxide

PMID:11469800
increases expressionISORGD:7330196480464CTDHydrogen Peroxide results in increased expression of PRDX2 mRNA, Hydrogen Peroxide results in increased expression of PRDX2 protein

PMID:11295360, PMID:9356316
increases oxidationISORGD:7330196480464CTDHydrogen Peroxide results in increased oxidation of PRDX2 protein

PMID:23543738
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.