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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of GJA1 mRNAPMID:27154496
Gja1increases phosphorylationEXP 6480464CTDHydrogen Peroxide results in increased phosphorylation of GJA1 proteinPMID:19720069 PMID:27154496
Gja1multiple interactionsEXP 6480464CTDbeta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]; capsanthin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]; Plant Extracts inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]; resveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]PMID:19720069 PMID:27154496
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of GJA1 mRNAPMID:15761015
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