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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2405
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crk
Name: CRK proto-oncogene, adaptor protein
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crkincreases phosphorylationEXP 6480464CTDHydrogen Peroxide results in increased phosphorylation of CRK proteinPMID:16187300
Crkmultiple interactionsEXP 6480464CTDHydrogen Peroxide promotes the reaction [CRK protein binds to PTK2B protein]; tyrphostin B44 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CRK protein]PMID:16187300
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