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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDHydrogen Peroxide affects the expression of BAX mRNA; Hydrogen Peroxide affects the expression of BAX proteinPMID:17204550 PMID:17570061
Baxaffects localizationEXP 6480464CTDHydrogen Peroxide affects the localization of BAX proteinPMID:30104959
Baxincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of BAX mRNA; Hydrogen Peroxide results in increased expression of BAX proteinPMID:12414117 PMID:15683462 PMID:20041988 PMID:22081883 PMID:23352507 PMID:25451577 PMID:27525270 PMID:31326407 PMID:35901927 PMID:36305173
Baxmultiple interactionsEXP 6480464CTD1-butyl-8-(3-noradamantyl)-3-(3-hydroxypropyl)xanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]; 3,5-dicaffeoylquinic acid methyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; 5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]; calycopterin results in decreased susceptibility to [Hydrogen Peroxide results in increased expression of BAX protein]; gallein inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]; Hydrogen Peroxide results in increased expression of and affects the localization of BAX protein; hyperoside inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Indomethacin inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Indomethacin inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein]; Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein]; N(6)-cyclopentyladenosine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of BAX protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; RLN2 protein affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; RLN2 protein affects the reaction [Hydrogen Peroxide affects the expression of BAX protein]; Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; trilobatin inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]PMID:12414117 PMID:15683462 PMID:17204550 PMID:17570061 PMID:20041988 PMID:22081883 PMID:23352507 PMID:25451577 PMID:25726415 PMID:27525270 PMID:30104959 PMID:31326407 PMID:35901927
Baxaffects expressionISOBax (Mus musculus)6480464CTDHydrogen Peroxide affects the expression of BAX mRNAPMID:27057282
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of BAX mRNAPMID:21179406
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDHydrogen Peroxide affects the localization of BAX proteinPMID:21742779
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of BAX mRNA; Hydrogen Peroxide results in decreased expression of BAX proteinPMID:12419474 PMID:20433247
Baxincreases activityISOBAX (Homo sapiens)6480464CTDHydrogen Peroxide results in increased activity of BAX proteinPMID:20525898
Baxincreases expressionISOBax (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of BAX mRNA; Hydrogen Peroxide results in increased expression of BAX proteinPMID:25242411 PMID:31696622
Baxincreases expressionISOBAX (Homo sapiens)6480464CTD[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein; Hydrogen Peroxide results in increased expression of BAX mRNA; Hydrogen Peroxide results in increased expression of BAX proteinPMID:12672908 PMID:15081873 PMID:16259763 PMID:17395767 PMID:20361964 PMID:22245672 PMID:22269385 PMID:23041154 PMID:23639522 PMID:23726866 PMID:25005833 PMID:25108166 PMID:26164594 PMID:27842206 PMID:28213291 PMID:29687528 PMID:31157476 PMID:31173752 PMID:31306736 PMID:31313457 PMID:32043704 PMID:33212048 PMID:33709623 PMID:35202708 PMID:36058301 PMID:36796651 PMID:37648050
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDGrape Seed Proanthocyanidins inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of BAX]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]PMID:21552291 PMID:25242411 PMID:27057282
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2''-galloylhyperin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; [[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; BECN1 protein affects the reaction [Hydrogen Peroxide affects the localization of BAX protein]; Deferoxamine inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]; dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; EUK-172 inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; HGF protein inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; HIF1A protein affects the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Hydrogen Peroxide promotes the reaction [TP53 protein results in increased expression of BAX]; kahweol inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Kangen-karyu inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; KISS1 protein affects the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; kukoamine B inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; nobiletin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Ozone inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; PIK3C3 protein promotes the reaction [Hydrogen Peroxide results in increased activity of BAX protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; SN50 peptide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]PMID:12672908 PMID:15081873 PMID:15142122 PMID:16259763 PMID:20361964 PMID:20525898 PMID:21552291 PMID:21621595 PMID:21742779 PMID:23041154 PMID:23639522 PMID:25005833 PMID:25108166 PMID:26164594 PMID:27842206 PMID:28213291 PMID:29687528 PMID:31173752 PMID:31306736 PMID:31313457 PMID:32043704 PMID:33212048 PMID:36058301 PMID:37648050
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