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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595860
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ezh2affects expressionISOEZH2 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of EZH2 mRNAPMID:20044591 PMID:21179406
Ezh2multiple interactionsISOEZH2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein]; Hydrogen Peroxide results in increased phosphorylation of and affects the localization of EZH2 proteinPMID:24582688
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