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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353723
Species: Homo sapiens
RGD Object: Gene
Symbol: PGK1
Name: phosphoglycerate kinase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGK1increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of PGK1 proteinPMID:18603805
PGK1multiple interactionsEXP 6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein]; delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein]PMID:18603805
PGK1decreases expressionISOPgk1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in decreased expression of PGK1 proteinPMID:23178681
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