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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315043
Species: Homo sapiens
RGD Object: Gene
Symbol: MAP3K5
Name: mitogen-activated protein kinase kinase kinase 5
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAP3K5multiple interactionsEXP 6480464CTDASK1 protein inhibits the reaction [Hydrogen Peroxide promotes the reaction [MAP3K5 protein binds to MAP2K7 protein]]; Hydrogen Peroxide promotes the reaction [MAP3K5 protein binds to MAP2K7 protein]PMID:28939911
MAP3K5increases activityISOMap3k5 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased activity of MAP3K5 proteinPMID:15629441
MAP3K5increases expressionISOMap3k5 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased expression of MAP3K5 proteinPMID:16157298
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