GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Brd4 | multiple interactions | ISO | BRD4 (Homo sapiens) | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]]; (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]]; [Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]; [Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]; BRD4 mutant form inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; BRD4 mutant form inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]]; Hydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [BRD4 protein binds to CXCL8 promoter]]; Hydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [BRD4 protein binds to IL6 promoter]] | PMID:24759736 | | ||||||||||||||||||||||
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