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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1affects splicingISOXBP1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the splicing of XBP1 mRNAPMID:23885834
Xbp1decreases response to substanceISOXBP1 (Homo sapiens)6480464CTDXBP1 protein results in decreased susceptibility to Hydrogen PeroxidePMID:21138464
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of XBP1 protein alternative formPMID:23885834
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]; XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]PMID:21138464
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