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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of EGF mRNA

PMID:17997286
multiple interactionsEXP 6480464CTDSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGF mRNA]

PMID:17997286
increases expressionISORGD:7368326480464CTDHydrogen Peroxide results in increased expression of EGF

PMID:30265530
multiple interactionsISORGD:7368326480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF], perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]

PMID:30265530
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.