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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases abundanceISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased abundance of Hydrogen PeroxidePMID:25061110
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of CYP1A2 mRNA; Hydrogen Peroxide results in increased expression of CYP1A2 proteinPMID:36368423
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Hydrogen Peroxide results in increased expression of CYP1A2 mRNA]PMID:36368423
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