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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736587
Species: Mus musculus
RGD Object: Gene
Symbol: Scd1
Name: stearoyl-Coenzyme A desaturase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scd1decreases expressionEXP 6480464CTDEthanol results in decreased expression of SCD1 proteinPMID:28882574
Scd1increases expressionEXP 6480464CTDEthanol results in increased expression of SCD1 mRNAPMID:12036955 PMID:18620774 PMID:18755807 PMID:19167417 PMID:20637825 PMID:24144995 PMID:24146112 PMID:30319688
Scd1multiple interactionsEXP 6480464CTD[ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of SCD1 mRNA; [Zinc deficiency co-treated with Ethanol] affects the expression of SCD1 mRNA; Ethanol inhibits the reaction [Fish Oils results in decreased expression of SCD1 mRNA]; gadolinium chloride promotes the reaction [Ethanol results in decreased expression of SCD1 protein]; resveratrol inhibits the reaction [Ethanol results in increased expression of SCD1 mRNA]PMID:18620774 PMID:18755807 PMID:23692951 PMID:24155903 PMID:28882574
Scd1decreases expressionISOScd (Rattus norvegicus)6480464CTDEthanol results in decreased expression of SCD1 mRNAPMID:31078653
Scd1increases expressionISOScd (Rattus norvegicus)6480464CTDEthanol results in increased expression of SCD1 mRNAPMID:19371623 PMID:24146112
Scd1multiple interactionsISOScd (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of SCD mRNA]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of SCD mRNA; [Fish Oils co-treated with Ethanol] results in increased expression of SCD1 mRNAPMID:17347304 PMID:35872049
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