GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | decreases expression | ISO | Nr1h4 (Rattus norvegicus) | 15036816 | RGD | ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine | | Nr1h4 | increases response to substance | EXP | | 6480464 | CTD | NR1H4 gene mutant form results in increased susceptibility to Ethanol | PMID:25460735 | Nr1h4 | multiple interactions | EXP | | 6480464 | CTD | [NR1H4 gene mutant form results in increased susceptibility to Ethanol] which results in increased activity of ALT protein; [NR1H4 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of AKT1 protein; Ethanol promotes the reaction [NR1H4 gene mutant form results in decreased expression of NR0B2 mRNA]; NR1H4 gene mutant form inhibits the reaction [Ethanol affects the localization of FOXO3 protein]; NR1H4 gene mutant form inhibits the reaction [Ethanol promotes the reaction [FOXO3 protein binds to MAP1LC3B promoter]]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased degradation of MFN1 protein]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased degradation of MFN2 protein]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of and results in decreased phosphorylation of FOXO3 protein]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of ATG5 mRNA]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of BECN1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of CCND1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of FOXO3 mRNA]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of MAP1LC3B mRNA]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of SOD2 mRNA]; NR1H4 gene mutant form promotes the reaction [Ethanol results in increased expression of SQSTM1 protein] | PMID:25460735 | Nr1h4 | decreases expression | ISO | Nr1h4 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in decreased expression of NR1H4 mRNA; Ethanol results in decreased expression of NR1H4 protein | PMID:16946407 PMID:34217791 | Nr1h4 | decreases expression | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Ethanol results in decreased expression of NR1H4 mRNA; Ethanol results in decreased expression of NR1H4 protein | PMID:27939985 PMID:34217791 PMID:35149083 | Nr1h4 | multiple interactions | ISO | Nr1h4 (Rattus norvegicus) | 6480464 | CTD | 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of NR1H4 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of NR1H4 protein | PMID:35872049 | Nr1h4 | multiple interactions | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of FASN protein]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; artenimol inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; artenimol inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; artenimol promotes the reaction [NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of NR1H4 mRNA]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of NR1H4 protein]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; NR1H4 protein inhibits the reaction [Ethanol results in increased activity of GPT protein]; NR1H4 protein inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; NR1H4 protein inhibits the reaction [Ethanol results in increased expression of FASN protein]; NR1H4 protein inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; NR1H4 protein inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; NR1H4 protein promotes the reaction [artenimol inhibits the reaction [Ethanol results in increased activity of GPT protein]] | PMID:27939985 | | ||||||||||||||||||||||
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