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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases expressionEXP 6480464CTDEthanol results in decreased expression of AKT1 mRNAPMID:31226463
AKT1increases phosphorylationEXP 6480464CTDEthanol results in increased phosphorylation of AKT1 proteinPMID:26220687 PMID:33516933
AKT1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of AKT1 protein]; [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of AKT1 mRNA; Ethanol promotes the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Ethanol results in increased phosphorylation of and results in increased activity of AKT1 protein; sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of AKT1 protein]PMID:18295389 PMID:26220687 PMID:29432896 PMID:33516933
AKT1affects expressionISOAkt1 (Rattus norvegicus)6480464CTDEthanol affects the expression of AKT1 mRNAPMID:31039417
AKT1decreases expressionISOAkt1 (Rattus norvegicus)6480464CTDEthanol results in decreased expression of AKT1 mRNAPMID:31226463
AKT1decreases expressionISOAkt1 (Mus musculus)6480464CTDEthanol results in decreased expression of AKT1 mRNAPMID:29524503
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDEthanol results in decreased phosphorylation of AKT1 proteinPMID:17685400
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDEthanol results in decreased phosphorylation of AKT1 proteinPMID:24095927 PMID:24892905 PMID:28131861 PMID:34687774
AKT1increases expressionISOAkt1 (Rattus norvegicus)6480464CTDEthanol results in increased expression of AKT1 mRNAPMID:35608386
AKT1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDEthanol results in increased phosphorylation of AKT1 proteinPMID:22459179 PMID:28962519
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA; [Ethanol results in decreased susceptibility to INS1 protein] which results in increased activity of AKT1 protein; [Fish Oils co-treated with Ethanol] results in increased expression of AKT1 mRNA; Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; Ethanol results in decreased activity of and results in decreased phosphorylation of AKT1 protein; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA]; Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA]PMID:12700235 PMID:17347304 PMID:35066094 PMID:35608386
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTD[Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased phosphorylation of AKT1 protein; [NR1H4 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of AKT1 protein; Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of AKT1 protein]; Ethanol affects the expression of and affects the splicing of AKT1 mRNA; Ethanol inhibits the reaction [BMP7 protein results in increased phosphorylation of AKT1 protein]PMID:24892905 PMID:25460735 PMID:30319688 PMID:34687774 PMID:37406968
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