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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732865
Species: Homo sapiens
RGD Object: Gene
Symbol: PRKAA1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRKAA1multiple interactionsEXP 6480464CTDPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of CASP1 mRNA]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK4 protein]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]]; PRKAA1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 mRNA]]PMID:24582693 PMID:28964808
PRKAA1multiple interactionsISOPrkaa1 (Mus musculus)6480464CTD[Ethanol co-treated with PRKAA2 protein] affects the expression of PRKAA1 proteinPMID:23448468
PRKAA1multiple interactionsISOPrkaa1 (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased phosphorylation of PRKAA1 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased phosphorylation of PRKAA1 proteinPMID:35872049
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