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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1decreases expressionEXP 6480464CTDEthanol results in decreased expression of HMOX1 mRNA; Ethanol results in decreased expression of HMOX1 proteinPMID:22484158 PMID:34474091 PMID:35713687
HMOX1increases activityEXP 6480464CTDEthanol results in increased activity of HMOX1 proteinPMID:17433488
HMOX1increases expressionEXP 6480464CTDEthanol results in increased expression of HMOX1 mRNA; Ethanol results in increased expression of HMOX1 proteinPMID:15602829 PMID:17295091
HMOX1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]]; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol; [Ethanol co-treated with Benzo(a)pyrene] results in increased expression of HMOX1 mRNA; [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Iron; HECTD4 protein promotes the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]; Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]PMID:15602829 PMID:17433488 PMID:22484158 PMID:34474091 PMID:35412187 PMID:35713687
HMOX1decreases activityISOHmox1 (Rattus norvegicus)6480464CTDEthanol results in decreased activity of HMOX1 proteinPMID:20080166
HMOX1decreases expressionISOHmox1 (Mus musculus)6480464CTDEthanol results in decreased expression of HMOX1 mRNA; Ethanol results in decreased expression of HMOX1 proteinPMID:22552773 PMID:24144995 PMID:27983966 PMID:28419832
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDEthanol results in decreased expression of HMOX1 mRNA; Ethanol results in decreased expression of HMOX1 proteinPMID:25111957 PMID:26460608 PMID:30372842 PMID:32151596 PMID:34346143
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDEthanol results in increased expression of HMOX1 mRNA; Ethanol results in increased expression of HMOX1 proteinPMID:20861358 PMID:25449124 PMID:34590183 PMID:34995708
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDEthanol results in increased expression of HMOX1 mRNAPMID:26460608
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[Ethanol co-treated with ethylene dichloride] results in increased expression of HMOX1 protein; allyl sulfide inhibits the reaction [[Ethanol co-treated with ethylene dichloride] results in increased expression of HMOX1 protein]; dihydromyricetin inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]; Drugs, Chinese Herbal inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Ethanol promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; Ethanol promotes the reaction [ethylene dichloride results in increased expression of HMOX1 mRNA]; Ethanol promotes the reaction [ethylene dichloride results in increased expression of HMOX1 protein]; Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]PMID:20861358 PMID:27983966 PMID:28419832 PMID:30664321 PMID:37150348
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA; Arbutin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Ethanol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA]; Ethanol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; Ethanol promotes the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA]; Ethanol promotes the reaction [ADIPOQ protein results in increased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Quercetin results in decreased susceptibility to Ethanol]; IL10 protein promotes the reaction [Ethanol promotes the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA]]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]; p-coumaric acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]; Silymarin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; tricarbonyldichlororuthenium (II) dimer affects the reaction [Ethanol results in decreased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ethanol results in increased expression of HMOX1 mRNA]PMID:20052772 PMID:20080166 PMID:22056766 PMID:25111957 PMID:26460608 PMID:26747958 PMID:30372842 PMID:32151596 PMID:34346143
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