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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDEthanol affects the localization of SREBF1 protein

PMID:19371623
decreases expressionEXP 6480464CTDEthanol results in decreased expression of SREBF1 mRNA

PMID:16098508
increases expressionEXP 6480464CTDEthanol results in increased expression of SREBF1 mRNA, Ethanol results in increased expression of SREBF1 protein

PMID:12036955, PMID:19371623, PMID:22413959, PMID:24146112, PMID:26115886, PMID:26854922, PMID:27795452
multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Ethanol] results in increased expression of SREBF1 mRNA, [Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein, carvedilol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter], Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein, honokiol inhibits the reaction [Ethanol affects the localization of SREBF1 protein], honokiol inhibits the reaction [Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter]], honokiol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], Plant Extracts inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], resveratrol inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein], Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], Silymarin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], SIRT1 protein inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein]

PMID:18239056, PMID:19371623, PMID:22413959, PMID:24275070, PMID:26115886, PMID:26854922, PMID:27795452
decreases expressionISORGD:694736480464CTDEthanol results in decreased expression of SREBF1 protein

PMID:28062356
decreases expressionISORGD:694746480464CTDEthanol results in decreased expression of SREBF1 mRNA

PMID:22173916, PMID:28882574
increases activityISORGD:694746480464CTDEthanol results in increased activity of SREBF1 protein

PMID:18620774
increases expressionISORGD:694736480464CTDEthanol results in increased expression of SREBF1 mRNA, Ethanol results in increased expression of SREBF1 protein

PMID:22138249, PMID:27939985, PMID:29476730
increases expressionISORGD:694746480464CTDEthanol results in increased expression of SREBF1 mRNA, Ethanol results in increased expression of SREBF1 protein

PMID:18620774, PMID:18755807, PMID:19167417, PMID:22138249, PMID:22459179, PMID:22627062, PMID:24144995, PMID:24146112, PMID:27837167, PMID:28964808, PMID:29476730, PMID:30319688
multiple interactionsISORGD:694736480464CTD5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], [dihydroartemisinin co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], dihydroartemisinin inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], HIF1A protein inhibits the reaction [5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]], NR1H4 protein inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], NR1H4 protein inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], obeticholic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]

PMID:22138249, PMID:27939985, PMID:29476730
multiple interactionsISORGD:694746480464CTD5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], [Dietary Fats deficiency co-treated with Ethanol] results in increased expression of SREBF1 protein, [Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of and results in increased localization of and results in increased activity of SREBF1 protein, [PPARD gene mutant form results in increased susceptibility to Ethanol] which results in increased activity of SREBF1 protein, acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], allyl sulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], HIF1A protein inhibits the reaction [5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]], NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]], NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]], NFE2L2 protein affects the reaction [Ethanol results in increased expression of SREBF1 mRNA], pirinixic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], Resveratrol inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], Rosiglitazone inhibits the reaction [Ethanol results in decreased expression of SREBF1 mRNA], tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA], tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]

PMID:12036955, PMID:18239056, PMID:18620774, PMID:18755807, PMID:22138249, PMID:22173916, PMID:22627062, PMID:23851158, PMID:27837167, PMID:28964808, PMID:29476730
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.