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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aaffects expressionEXP 6480464CTDEthanol affects the expression of CDKN1A mRNAPMID:11772933
Cdkn1adecreases expressionEXP 6480464CTDEthanol results in decreased expression of CDKN1A mRNAPMID:34547370
Cdkn1aincreases expressionEXP 6480464CTDEthanol results in increased expression of CDKN1A mRNAPMID:11181050
Cdkn1amultiple interactionsEXP 6480464CTD[Ethanol co-treated with Cyanamide] results in decreased expression of CDKN1A mRNAPMID:12003908
Cdkn1aaffects expressionISOCdkn1a (Mus musculus)6480464CTDEthanol affects the expression of CDKN1A mRNAPMID:30319688
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDEthanol results in increased expression of CDKN1A mRNA; Ethanol results in increased expression of CDKN1A proteinPMID:34192554 PMID:34405320
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDEthanol results in increased expression of CDKN1A mRNA; Ethanol results in increased expression of CDKN1A proteinPMID:34192554 PMID:34405320
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTDCCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]]; NFATC4 protein affects the reaction [Ethanol results in increased expression of CDKN1A mRNA]; NFATC4 protein affects the reaction [Ethanol results in increased expression of CDKN1A protein]; PPARA protein affects the reaction [NFATC4 protein affects the reaction [Ethanol results in increased expression of CDKN1A protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of CDKN1A protein]]PMID:34192554 PMID:34405320
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDKN1A mRNA; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]]; NFATC4 protein affects the reaction [Ethanol results in increased expression of CDKN1A mRNA]; NFATC4 protein affects the reaction [Ethanol results in increased expression of CDKN1A protein]; pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of CDKN1A protein]]PMID:29432896 PMID:34192554 PMID:34405320
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