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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDEthanol results in increased activity of ALDH2 protein

PMID:22022451
increases expressionEXP 6480464CTDEthanol results in increased expression of ALDH2 mRNA

PMID:22554647, PMID:30319688
increases response to substanceEXP 6480464CTDALDH2 gene mutant form results in increased susceptibility to Ethanol

PMID:25155611, PMID:30721697
multiple interactionsEXP 6480464CTD[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein, [Zinc co-treated with Ethanol] results in increased expression of ALDH2 mRNA, ALDH2 protein inhibits the reaction [Ethanol affects the abundance of Calcium], ALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased expression of NCF1 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein], ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of CREB1 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GATA4 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein], ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of MAP3K5 protein], taraxerone promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]

PMID:17590987, PMID:19332462, PMID:19637192, PMID:20118189, PMID:22554647
affects metabolic processingISORGD:692206480464CTDALDH2 gene polymorphism affects the metabolism of Ethanol

PMID:29923378
affects response to substanceISORGD:692196480464CTDALDH2 protein affects the susceptibility to Ethanol

PMID:12439222
affects response to substanceISORGD:692206480464CTDALDH2 gene polymorphism affects the susceptibility to Ethanol, ALDH2 protein affects the susceptibility to Ethanol

PMID:10780266, PMID:15840430, PMID:22960999
decreases response to substanceISORGD:692206480464CTDALDH2 protein results in decreased susceptibility to Ethanol

PMID:19429258
increases activityISORGD:692196480464CTDEthanol results in increased activity of ALDH2 protein

PMID:23500772
increases expressionISORGD:692196480464CTDEthanol results in increased expression of ALDH2 protein

PMID:23200777
increases expressionISORGD:692206480464CTDEthanol results in increased expression of ALDH2 mRNA

PMID:22056336
increases metabolic processingISORGD:692206480464CTDALDH2 protein results in increased metabolism of Ethanol

PMID:10064379, PMID:10826103
increases response to substanceISORGD:692206480464CTDALDH2 protein results in increased susceptibility to Ethanol

PMID:15840430
multiple interactionsISORGD:692196480464CTD[N-Methyl-3, 4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased susceptibility to Ethanol, Ethanol inhibits the reaction [Streptozocin results in decreased expression of ALDH2]

PMID:19446252, PMID:23500772
multiple interactionsISORGD:6921915036805RGDethanol increases 4-hydroxynonenal-Aldh2 protein adduct formation, increases acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver

 
multiple interactionsISORGD:692206480464CTDALDH2 protein inhibits the reaction [Ethanol results in decreased expression of BCL2 protein], ALDH2 protein inhibits the reaction [Ethanol results in decreased expression of NOL3 protein], ALDH2 protein inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein], ALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased expression of BAX protein], ALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein], ALDH2 protein inhibits the reaction [Ethanol results in increased expression of XIAP protein], resveratrol promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]

PMID:19429258, PMID:22056336
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.