GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | affects expression | EXP | | 6480464 | CTD | Ethanol affects the expression of PPARG mRNA | PMID:19167417 | Pparg | decreases expression | EXP | | 6480464 | CTD | Ethanol results in decreased expression of PPARG mRNA; Ethanol results in decreased expression of PPARG protein | PMID:22173916 PMID:34192554 | Pparg | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of PPARG mRNA; Ethanol results in increased expression of PPARG protein | PMID:18620774 PMID:18755807 PMID:20007851 PMID:24144995 PMID:28964808 PMID:34116071 PMID:37271273 | Pparg | multiple interactions | EXP | | 6480464 | CTD | [ADORA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased expression of PPARG mRNA; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of PPARG mRNA; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of PPARG protein; [Ethanol co-treated with Carbon Tetrachloride co-treated with 4-O-methylhonokiol] results in decreased expression of PPARG mRNA; [Ethanol co-treated with Diethylhexyl Phthalate] results in increased expression of PPARG mRNA; [Palmitic Acid co-treated with Ethanol] results in increased expression of PPARG mRNA; [Rosiglitazone co-treated with Ethanol] results in increased expression of PPARG mRNA; acanthoic acid inhibits the reaction [Ethanol results in increased expression of PPARG protein]; Ethanol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG mRNA]; NFATC4 protein affects the reaction [Ethanol results in decreased expression of PPARG protein]; NFE2L2 gene mutant form inhibits the reaction [Ethanol results in increased expression of PPARG protein]; PER1 gene mutant form inhibits the reaction [Ethanol results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [NFATC4 protein affects the reaction [Ethanol results in increased expression of IL1A protein]]; PPARG protein affects the reaction [NFATC4 protein affects the reaction [Ethanol results in increased expression of IL6 protein]]; Resveratrol inhibits the reaction [Ethanol results in increased expression of PPARG mRNA]; Rosiglitazone inhibits the reaction [Ethanol results in decreased expression of PPARG mRNA] | PMID:18755807 PMID:20007851 PMID:22173916 PMID:23692951 PMID:24144995 PMID:28689299 PMID:28964808 PMID:32171850 PMID:32325186 PMID:34116071 PMID:34192554 PMID:37271273 | Pparg | decreases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | [Ethanol results in decreased expression of PPARG protein] which results in decreased expression of ADIPOQ protein; Ethanol results in decreased expression of PPARG mRNA; Ethanol results in decreased expression of PPARG protein | PMID:24412557 | Pparg | decreases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Ethanol results in decreased expression of PPARG mRNA; Ethanol results in decreased expression of PPARG protein | PMID:28062356 PMID:34192554 | Pparg | increases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | Ethanol results in increased expression of PPARG mRNA; Ethanol results in increased expression of PPARG protein | PMID:18793633 PMID:26220516 PMID:26854922 PMID:37024064 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Ethanol results in increased expression of PPARG mRNA | PMID:24144995 | Pparg | multiple interactions | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | [Ethanol co-treated with Lipopolysaccharides] results in decreased expression of PPARG mRNA; [Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [Ethanol results in increased expression of PPARG mRNA]; Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA]; Ethanol promotes the reaction [PPARG protein binds to HDAC3 protein binds to SUV39H1 protein]; HOTAIR affects the reaction [Ethanol results in increased expression of PPARG protein]; MIR122 inhibits the reaction [Ethanol results in increased expression of PPARG protein]; Pioglitazone inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of PPARG mRNA]; Resveratrol inhibits the reaction [Ethanol results in increased expression of PPARG mRNA]; SB 203580 inhibits the reaction [Ethanol results in decreased expression of PPARG protein] | PMID:15318101 PMID:18793633 PMID:24412557 PMID:26854922 PMID:37024064 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Cyanamide inhibits the reaction [Ethanol inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]]; Ethanol inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased activity of PPARG protein]; Ethanol inhibits the reaction [Pioglitazone results in increased activity of PPARG protein]; Ethanol inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]; Fomepizole inhibits the reaction [Ethanol inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]]; NFATC4 protein affects the reaction [Ethanol results in decreased expression of PPARG mRNA]; NFATC4 protein affects the reaction [Ethanol results in decreased expression of PPARG protein]; PER1 protein promotes the reaction [Ethanol results in increased expression of PPARG mRNA] | PMID:17030193 PMID:24144995 PMID:34192554 | | ||||||||||||||||||||||
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