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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEthanol results in increased expression of CCND1 protein

PMID:18506933
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Ethanol results in increased expression of CCND1 protein]

PMID:18506933
affects expressionISORGD:685576480464CTDEthanol affects the expression of CCND1 mRNA

PMID:30319688
affects splicingISORGD:685576480464CTDEthanol affects the splicing of CCND1 mRNA

PMID:30319688
increases expressionISORGD:685566480464CTDEthanol results in increased expression of CCND1 mRNA

PMID:12720008
increases expressionISORGD:685576480464CTDEthanol results in increased expression of CCND1 mRNA

PMID:25460735, PMID:30319688
multiple interactionsISORGD:685576480464CTDNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of CCND1 mRNA]

PMID:25460735
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.