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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases activityEXP 6480464CTDEthanol results in increased activity of MMP9 proteinPMID:20465419
Mmp9increases expressionEXP 6480464CTDEthanol results in increased expression of MMP9 mRNA; Ethanol results in increased expression of MMP9 proteinPMID:17603938 PMID:17887948 PMID:21360558 PMID:23155471 PMID:29769550
Mmp9increases secretionEXP 6480464CTDEthanol results in increased secretion of MMP9 proteinPMID:22257724
Mmp9multiple interactionsEXP 6480464CTD[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of MMP9 mRNA; [Ethanol co-treated with Dietary Fats] results in increased expression of MMP9 mRNA; [Quercetin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; [Quercetin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]; [Sunflower Oil analog co-treated with Ethanol] results in decreased activity of MMP9 protein; Acetylcysteine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; BDMC-A inhibits the reaction [[Sunflower Oil analog co-treated with Ethanol] results in decreased activity of MMP9 protein]; BDMC-A inhibits the reaction [Ethanol results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Dimethyl Sulfoxide inhibits the reaction [Ethanol results in increased activity of MMP9 protein]; Ethanol affects the reaction [ochratoxin A results in increased expression of MMP9 protein]; Ethanol results in increased expression of and results in increased activity of MMP9 protein; Ethanol results in increased secretion of and results in increased activity of MMP9 protein; Famotidine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Famotidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]; Lipopolysaccharides promotes the reaction [Ethanol results in increased expression of MMP9 mRNA]; lipostabil inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]; Ranitidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]PMID:16622519 PMID:17603938 PMID:17887948 PMID:20465419 PMID:21051528 PMID:22257724
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDEthanol results in increased expression of MMP9 mRNAPMID:31059573
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDEthanol results in increased expression of MMP9 mRNAPMID:30319688
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