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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619574
Species: Homo sapiens
RGD Object: Gene
Symbol: GFAP
Name: glial fibrillary acidic protein
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GFAPincreases expressionEXP 6480464CTDEthanol results in increased expression of GFAP proteinPMID:20621659
GFAPaffects expressionISOGfap (Rattus norvegicus)6480464CTDEthanol affects the expression of GFAP mRNA; Ethanol affects the expression of GFAP proteinPMID:17262233 PMID:34547370
GFAPaffects splicingISOGfap (Mus musculus)6480464CTDEthanol affects the splicing of GFAP mRNAPMID:30319688
GFAPdecreases expressionISOGfap (Mus musculus)6480464CTDEthanol results in decreased expression of GFAP mRNAPMID:21955143
GFAPdecreases expressionISOGfap (Rattus norvegicus)6480464CTDEthanol results in decreased expression of GFAP mRNA; Ethanol results in decreased expression of GFAP proteinPMID:16770775 PMID:20837132
GFAPincreases expressionISOGfap (Mus musculus)6480464CTDEthanol results in increased expression of GFAP mRNA; Ethanol results in increased expression of GFAP proteinPMID:23500890 PMID:30319688
GFAPincreases expressionISOGfap (Rattus norvegicus)6480464CTDEthanol results in increased expression of GFAP proteinPMID:17888892
GFAPmultiple interactionsISOGfap (Mus musculus)6480464CTDEthanol promotes the reaction [Dietary Fats results in increased expression of GFAP mRNA]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of GFAP protein]PMID:23500890 PMID:35863473
GFAPmultiple interactionsISOGfap (Rattus norvegicus)6480464CTD[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Ethanol] results in increased expression of GFAP mRNA; Calcium deficiency inhibits the reaction [Ethanol results in increased expression of GFAP protein]; Resveratrol inhibits the reaction [Ethanol results in increased expression of GFAP protein]PMID:17888892 PMID:30098312
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