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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61307
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncf1
Name: neutrophil cytosolic factor 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncf1affects localizationEXP 6480464CTDEthanol affects the localization of NCF1 proteinPMID:22497828 PMID:22982071
Ncf1increases activityEXP 6480464CTDEthanol results in increased activity of NCF1 proteinPMID:22497828
Ncf1increases expressionEXP 6480464CTDEthanol results in increased expression of NCF1 proteinPMID:21704112 PMID:22497828
Ncf1multiple interactionsEXP 6480464CTDginkgolide B inhibits the reaction [Ethanol results in increased expression of NCF1 protein]; Go 6976 inhibits the reaction [Ethanol affects the localization of NCF1 protein]; Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]; PRKCB protein affects the reaction [Ethanol results in increased expression of NCF1 protein]PMID:21704112 PMID:22497828 PMID:22982071
Ncf1increases expressionISONCF1 (Homo sapiens)6480464CTDEthanol results in increased expression of NCF1 proteinPMID:26079697
Ncf1increases expressionISONcf1 (Mus musculus)6480464CTDEthanol results in increased expression of NCF1 mRNA; Ethanol results in increased expression of NCF1 proteinPMID:19332462 PMID:22497828 PMID:27984176 PMID:30319688
Ncf1multiple interactionsISONcf1 (Mus musculus)6480464CTD5-aminoisoquinolinone inhibits the reaction [Ethanol results in increased expression of NCF1 mRNA]; [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of NCF1 mRNA; [Zinc deficiency co-treated with Ethanol] results in increased expression of NCF1 protein; ALDH2 protein inhibits the reaction [Ethanol results in increased expression of NCF1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased expression of NCF1 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of NCF1 mRNA]PMID:19332462 PMID:24155903 PMID:27984176 PMID:30517762
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