GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | affects expression | EXP | | 6480464 | CTD | Ethanol affects the expression of BAX mRNA; Ethanol affects the expression of BAX protein | PMID:25859307 PMID:29085585 | Bax | affects localization | EXP | | 6480464 | CTD | Ethanol affects the localization of BAX protein | PMID:16035105 | Bax | decreases expression | EXP | | 6480464 | CTD | Ethanol results in decreased expression of BAX mRNA | PMID:32497709 PMID:36453646 | Bax | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of BAX mRNA; Ethanol results in increased expression of BAX protein | PMID:12003908 PMID:23273579 PMID:26033013 PMID:28442378 PMID:29085585 PMID:30844427 PMID:31226463 PMID:32151596 PMID:37499997 | Bax | multiple interactions | EXP | | 6480464 | CTD | 2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide inhibits the reaction [Ethanol results in increased expression of BAX protein]; 2-aminoethyl diphenylborinate inhibits the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; Cannabinoids inhibits the reaction [Ethanol results in decreased expression of BAX mRNA]; caraway oil inhibits the reaction [Ethanol affects the expression of BAX mRNA]; caraway oil inhibits the reaction [Ethanol affects the expression of BAX protein]; carvacrol inhibits the reaction [Ethanol results in increased expression of BAX protein]; corosolic acid inhibits the reaction [Ethanol results in increased expression of BAX protein]; Ethanol affects the reaction [BAX protein binds to BCL2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; Ethanol promotes the reaction [BAX protein binds to BCL2L1 protein]; Lanthanoid Series Elements inhibits the reaction [Ethanol results in increased expression of BAX protein]; p-coumaric acid inhibits the reaction [Ethanol results in increased expression of BAX protein]; thymoquinone affects the reaction [Ethanol affects the expression of BAX mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased expression of BAX protein]; zingerone inhibits the reaction [Ethanol results in increased expression of BAX protein] | PMID:16035105 PMID:25859307 PMID:26033013 PMID:28442378 PMID:29085585 PMID:30844427 PMID:32151596 PMID:33314588 PMID:36453646 PMID:37499997 | Bax | affects response to substance | ISO | Bax (Mus musculus) | 6480464 | CTD | BAX protein affects the susceptibility to Ethanol | PMID:15977640 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of BAX mRNA; Ethanol results in increased expression of BAX protein | PMID:19429258 PMID:27983966 PMID:35181401 PMID:35639301 PMID:37271273 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Ethanol results in increased expression of BAX mRNA; Ethanol results in increased expression of BAX protein | PMID:24224909 PMID:31226463 PMID:35158046 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | 1-(quinoxalin-6-ylcarbonyl)piperidine inhibits the reaction [Ethanol results in increased expression of BAX protein]; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of BAX protein; Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]; Drugs, Chinese Herbal inhibits the reaction [Ethanol results in increased expression of BAX protein]; sodium propionate inhibits the reaction [Ethanol results in increased expression of BAX mRNA] | PMID:27983966 PMID:35181401 PMID:35639301 PMID:37271273 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | ALDH2 protein inhibits the reaction [Ethanol results in increased expression of BAX protein]; Ethanol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]; IGF1 protein inhibits the reaction [Ethanol results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [Ethanol results in increased expression of BAX protein]; Silybin inhibits the reaction [Ethanol results in increased expression of BAX protein] | PMID:19429258 PMID:24224909 PMID:29803612 PMID:31226463 PMID:35158046 | | ||||||||||||||||||||||
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