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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352097
Species: Homo sapiens
RGD Object: Gene
Symbol: POMC
Name: proopiomelanocortin
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POMCdecreases expressionEXP 6480464CTDEthanol results in decreased expression of POMC mRNAPMID:17934066
POMCmultiple interactionsEXP 6480464CTDfomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA]PMID:17934066
POMCaffects response to substanceISOPomc (Rattus norvegicus)6480464CTDPOMC protein affects the susceptibility to EthanolPMID:20021565
POMCdecreases expressionISOPomc (Rattus norvegicus)6480464CTDEthanol results in decreased expression of POMC proteinPMID:32437893
POMCdecreases secretionISOPomc (Rattus norvegicus)6480464CTDEthanol results in decreased secretion of POMC protein alternative formPMID:12746300
POMCincreases expressionISOPomc (Rattus norvegicus)6480464CTDEthanol results in increased expression of POMC mRNA; Ethanol results in increased expression of POMC proteinPMID:16925589 PMID:7704432 PMID:9610951
POMCmultiple interactionsISOPomc (Rattus norvegicus)6480464CTD[Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA; [Ethanol co-treated with Cyanamide] results in decreased expression of POMC mRNA; [Ethanol co-treated with Cyanamide] results in increased expression of POMC mRNA; astressin B inhibits the reaction [Ethanol results in decreased secretion of POMC protein alternative form]; Ethanol results in increased expression of and results in increased secretion of POMC protein; POMC protein affects the reaction [Ethanol results in increased abundance of Steroids]; R 121919 inhibits the reaction [Ethanol results in decreased secretion of POMC protein alternative form]PMID:11139417 PMID:12746300 PMID:16375214 PMID:20021565
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