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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Adecreases expressionISOHspa1a (Mus musculus)6480464CTDEthanol results in decreased expression of HSPA1A mRNAPMID:19167417
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDEthanol results in increased expression of HSPA1A mRNA; Ethanol results in increased expression of HSPA1A proteinPMID:17189318
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTDgeranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein]; HSF1 protein affects the reaction [Ethanol results in increased expression of HSPA1A mRNA]; HSF1 protein affects the reaction [Ethanol results in increased expression of HSPA1A protein]PMID:17189318
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