GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | increases cleavage | EXP | | 6480464 | CTD | Ethanol results in increased cleavage of PARP1 protein | PMID:21410490 PMID:24374569 PMID:33516933 PMID:35158046 | PARP1 | multiple interactions | EXP | | 6480464 | CTD | Ethanol results in increased expression of and results in increased cleavage of PARP1 protein; Silybin inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein]; Sirolimus inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein] | PMID:21410490 PMID:35149083 PMID:35158046 | PARP1 | affects splicing | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Ethanol affects the splicing of PARP1 mRNA | PMID:30319688 | PARP1 | increases activity | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased activity of PARP1 protein | PMID:27984176 | PARP1 | increases activity | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in increased activity of PARP1 protein | PMID:30368987 | PARP1 | increases cleavage | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased cleavage of PARP1 protein | PMID:22535522 PMID:34116071 | PARP1 | increases expression | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of PARP1 protein | PMID:24146112 PMID:29317476 | PARP1 | increases expression | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in increased expression of PARP1 mRNA; Ethanol results in increased expression of PARP1 protein | PMID:15353170 PMID:24146112 PMID:25029343 PMID:29339456 PMID:36085217 | PARP1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | 5-aminoisoquinolinone inhibits the reaction [Ethanol results in increased activity of PARP1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased activity of PARP1 protein]; NFE2L2 gene mutant form promotes the reaction [Ethanol results in increased cleavage of PARP1 protein]; PARP1 protein affects the reaction [Ethanol results in increased expression of ACACA mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of ACACB mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of CCL3 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of CCR2 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of CXCL2 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of CYBB mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of G6PC1 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of GCK mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of GPT protein]; PARP1 protein affects the reaction [Ethanol results in increased expression of ICAM1 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of IFNG mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of IL1B mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of MPO mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of NCF1 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of NOS2 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of SREBF1 mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of TNF mRNA] | PMID:24146112 PMID:27984176 PMID:34116071 | PARP1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] promotes the reaction [Ethanol results in increased expression of PARP1 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]; Docosahexaenoic Acids inhibits the reaction [Ethanol results in increased expression of PARP1 protein]; Ethanol promotes the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of PARP1 mRNA]; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] | PMID:24146112 PMID:25029343 PMID:30368987 PMID:36085217 | | ||||||||||||||||||||||
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