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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10821
Species: Mus musculus
RGD Object: Gene
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr1affects splicingEXP 6480464CTDEthanol affects the splicing of ITPR1 mRNAPMID:30319688
Itpr1increases expressionEXP 6480464CTDEthanol results in increased expression of ITPR1 mRNA; Ethanol results in increased expression of ITPR1 proteinPMID:29800586 PMID:30319688
Itpr1increases expressionISOITPR1 (Homo sapiens)6480464CTDEthanol results in increased expression of ITPR1 mRNAPMID:17241155
Itpr1multiple interactionsISOITPR1 (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]; Ethanol results in increased expression of and affects the localization of ITPR1 protein; fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]; ITPR1 protein promotes the reaction [Ethanol metabolite results in increased abundance of Calcium]; Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]; xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]PMID:17241155
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