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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1baffects secretionEXP 6480464CTDEthanol affects the secretion of IL1B proteinPMID:20624996
Il1bdecreases expressionEXP 6480464CTDEthanol results in decreased expression of IL1B mRNA; Ethanol results in decreased expression of IL1B proteinPMID:28843478 PMID:7473187
Il1bincreases expressionEXP 6480464CTDEthanol results in increased expression of IL1B mRNA; Ethanol results in increased expression of IL1B proteinPMID:23500890 PMID:24223948 PMID:26858005 PMID:27984176 PMID:28419832 PMID:28935932 PMID:28964808 PMID:31711802 PMID:31954762 PMID:33161052 PMID:35143882 PMID:35181401 PMID:35526736
Il1bmultiple interactionsEXP 6480464CTD1-(quinoxalin-6-ylcarbonyl)piperidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; 5-aminoisoquinolinone inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; [Ethanol co-treated with 4-Nitroquinoline-1-oxide] results in increased expression of IL1B mRNA; [Ethanol co-treated with Dietary Fats co-treated with 5-aminoisoquinolinone] results in decreased expression of IL1B mRNA; [Ethanol co-treated with Dietary Fats co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in decreased expression of IL1B mRNA; [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of IL1B mRNA; [Ethanol co-treated with Dietary Fats] results in increased expression of IL1B protein; [Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; [Ethanol co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B protein; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; [ethylene dichloride co-treated with Ethanol] results in increased expression of IL1B protein; [Fructose co-treated with Ethanol] results in increased expression of IL1B mRNA; [lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in increased expression of IL1B protein; [Zinc deficiency co-treated with Ethanol] results in increased expression of IL1B mRNA; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; ADORA2B protein inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of IL1B protein]; ADORA2B protein inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of IL1B protein]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Cannabidiol inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; CIRBP gene mutant form inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of IL1B protein]; dihydromyricetin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Ethanol results in increased expression of and results in increased secretion of IL1B protein; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of IL1B protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in increased expression of IL1B protein]; Mifepristone inhibits the reaction [Ethanol results in decreased expression of IL1B mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; PARP1 protein affects the reaction [Ethanol results in increased expression of IL1B mRNA]; platycodin D inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of IL1B protein]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of IL1B protein]PMID:19500611 PMID:23500890 PMID:24155903 PMID:24223948 PMID:25478868 PMID:25927324 PMID:26858005 PMID:27984176 PMID:28419832 PMID:28935932 PMID:28964808 PMID:31711802 PMID:31954762 PMID:33516661 PMID:35143882 PMID:35181401 PMID:35526736 PMID:35863473 PMID:37023972 PMID:37054933 PMID:37150348 PMID:37406968 PMID:7473187
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDEthanol results in decreased expression of IL1B proteinPMID:26733986
Il1bincreases cleavageISOIL1B (Homo sapiens)6480464CTDEthanol results in increased cleavage of IL1B proteinPMID:28964808
Il1bincreases expressionISOIl1b (Rattus norvegicus)6480464CTDEthanol results in increased expression of IL1B; Ethanol results in increased expression of IL1B mRNA; Ethanol results in increased expression of IL1B proteinPMID:17887948 PMID:23422878 PMID:25289771 PMID:26460608 PMID:26522475 PMID:27474069 PMID:28963034 PMID:29339218 PMID:30372842 PMID:33314588
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDEthanol results in increased expression of IL1B mRNA; Ethanol results in increased expression of IL1B proteinPMID:11344824 PMID:28964808 PMID:34474091
Il1bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of IL1B protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of IL1B protein; [Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein; acetovanillone inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; beta-patchoulene analog inhibits the reaction [Ethanol results in increased expression of IL1B protein]; chebulagic acid inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Lansoprazole inhibits the reaction [Ethanol results in increased expression of IL1B protein]; lipostabil inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; nymphayol inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Ethanol results in increased expression of IL1B]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]PMID:17887948 PMID:23422878 PMID:25289771 PMID:26460608 PMID:26522475 PMID:27474069 PMID:28963034 PMID:29339218 PMID:30372842 PMID:33314588 PMID:35872049
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of IL1B mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Ethanol results in increased expression of and results in increased secretion of IL1B protein; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1B protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of IL1B protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1B protein]]; TLR3 protein affects the reaction [Ethanol results in increased expression of and results in increased secretion of IL1B protein]PMID:28964808 PMID:29432896 PMID:33161052 PMID:34474091
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