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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10766
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor I receptor
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1raffects expressionEXP 6480464CTDEthanol affects the expression of IGF1R mRNAPMID:30319688
Igf1rdecreases expressionEXP 6480464CTDEthanol results in decreased expression of IGF1R mRNAPMID:29524503
Igf1rincreases expressionEXP 6480464CTDEthanol results in increased expression of IGF1R mRNAPMID:30319688
Igf1raffects expressionISOIgf1r (Rattus norvegicus)6480464CTDEthanol affects the expression of IGF1R mRNA; Ethanol affects the expression of IGF1R proteinPMID:31039417 PMID:32535229
Igf1rdecreases expressionISOIgf1r (Rattus norvegicus)6480464CTDEthanol results in decreased expression of IGF1R mRNA; Ethanol results in decreased expression of IGF1R protein modified formPMID:31226463
Igf1rdecreases expressionISOIGF1R (Homo sapiens)6480464CTDEthanol results in decreased expression of IGF1R mRNA; Ethanol results in decreased expression of IGF1R protein modified formPMID:29524503 PMID:31226463
Igf1rincreases activityISOIgf1r (Rattus norvegicus)6480464CTDEthanol results in increased activity of IGF1R proteinPMID:19735724
Igf1rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTD[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1R mRNA; Ethanol affects the reaction [Dietary Fats affects the expression of IGF1R mRNA]; Ethanol affects the reaction [Dietary Fats affects the expression of IGF1R protein]; Polysaccharides promotes the reaction [Ethanol results in increased activity of IGF1R protein]PMID:19735724 PMID:24275070 PMID:31811911
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