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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a23-3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
Acc ID: CHEBI:16227
Term: pyridine
Definition: An azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.
Chemical ID: MESH:C023666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a23-3a1increases activityEXP 6480464CTDpyridine results in increased activity of CYP3A23-3A1 proteinPMID:11181506
Cyp3a23-3a1increases expressionEXP 6480464CTDpyridine results in increased expression of CYP3A23-3A1 mRNA; pyridine results in increased expression of CYP3A23-3A1 proteinPMID:11181506
Cyp3a23-3a1multiple interactionsEXP 6480464CTDcordycepin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]PMID:11181506
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