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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736157
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCA1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCA1increases degradationEXP 6480464CTDOleic Acid results in increased degradation of ABCA1 proteinPMID:16118212
ABCA1increases phosphorylationEXP 6480464CTDOleic Acid results in increased phosphorylation of ABCA1 proteinPMID:16118212
ABCA1multiple interactionsEXP 6480464CTD[Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] affects the expression of ABCA1 mRNA; [Palmitic Acid co-treated with Oleic Acid] affects the expression of ABCA1 mRNA; Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]PMID:16118212 PMID:30547786
ABCA1increases expressionISOAbca1 (Mus musculus)6480464CTDOleic Acid results in increased expression of ABCA1 mRNAPMID:18356535
ABCA1multiple interactionsISOAbca1 (Mus musculus)6480464CTDOleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]PMID:18356535
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