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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69113
Species: Homo sapiens
RGD Object: Gene
Symbol: PDK4
Name: pyruvate dehydrogenase kinase 4
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PDK4increases expressionEXP 6480464CTDOleic Acid results in increased expression of PDK4 mRNAPMID:26739624
PDK4multiple interactionsEXP 6480464CTD[Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] results in increased expression of PDK4 mRNA; [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] results in increased expression of PDK4 protein; [Palmitic Acid co-treated with Oleic Acid] results in increased expression of PDK4 mRNA; [Palmitic Acid co-treated with Oleic Acid] results in increased expression of PDK4 proteinPMID:30547786
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