GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | increases expression | EXP | | 6480464 | CTD | Mercury results in increased expression of HMOX1 mRNA | PMID:12730625 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein] | PMID:27837179 | Hmox1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Mercury results in increased expression of HMOX1 mRNA | PMID:15297030 PMID:16093525 PMID:18078826 PMID:22579925 PMID:23231920 PMID:36245390 | Hmox1 | increases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Mercury results in increased expression of HMOX1 mRNA | PMID:17244614 PMID:17547211 PMID:26600472 | Hmox1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [beta-Naphthoflavone co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Mercury co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 protein; [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Tetrachlorodibenzodioxin co-treated with Mercury] results in increased expression of HMOX1 mRNA; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA]; Mercury results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Mercury results in increased expression of HMOX mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of HMOX1 mRNA] | PMID:15297030 PMID:18078826 PMID:22579925 PMID:23231920 PMID:36245390 | Hmox1 | multiple interactions | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter] | PMID:17244614 PMID:26600472 | | ||||||||||||||||||||||
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