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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303135
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Acc ID: CHEBI:161680
Term: aztreonam
Definition: A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Chemical ID: MESH:D001398
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npc1l1decreases expressionISONpc1l1 (Mus musculus)6480464CTDAztreonam results in decreased expression of NPC1L1 mRNAPMID:24657338
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