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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:16136
Term: hydrogen sulfide
Definition: A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
Chemical ID: MESH:D006862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDHydrogen Sulfide results in decreased phosphorylation of AKT1 proteinPMID:28741371
AKT1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDHydrogen Sulfide results in increased phosphorylation of AKT1 proteinPMID:31843631
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [Hydrogen Sulfide results in decreased phosphorylation of AKT1 protein]PMID:28741371
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