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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionEXP 6480464CTDDDT results in decreased expression of CDKN1A mRNAPMID:23684557
Cdkn1amultiple interactionsEXP 6480464CTDDDT inhibits the reaction [TRP53 protein binds to CDKN1A promoter]; DDT promotes the reaction [ESR1 protein binds to CDKN1A promoter]PMID:23684557
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDDDT results in decreased expression of CDKN1A mRNAPMID:33728745
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